Oral diazepam suppresses pentylenetetrazole-induced seizure-like behavior in adult zebrafish: A tool for nonclinical studies
نویسندگان
چکیده
Ethanolic extract of pomegranate (Punica granatum L) peel: acute toxicity tests on zebrafish (Danio rerio) embryos and its prediction by in silicoIndra Wibowo, Kurnia Permadi, Rika Hartati, Sophi Damayanti
منابع مشابه
The effect of hydroalcoholic extract of Salep on pentylenetetrazole-Induced Seizure in adult male Rats
Background: Epilepsy as a neurological disorder is characterized by unpredictable and periodic seizure. In the present study the anticonvulsant effect of different doses of salep hydroalcoholic extract on pentylenetetrazole (PTZ) induced seizures was investigated. Materials and Methods: The animal model of seizure was established by the intraperitoneal injection of pentylenetetrazole (PTZ- 85...
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Cyclooxygenases (COX)-1 and -2 are isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins (PGs). COX-2 and PGs are rapidly increased following seizures and are known to play important roles in the neuroinflammatory process. COX-2 isoform has been predominantly explored as the most suitable target for pharmacological intervention in epilepsy studies, while COX-1 remains ...
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Background and Objective: Copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. Previous studies have shown that copper sulfate () inhibits long-term potentiation (LTP) in slices of hippocampal CA1 region. Whereas LTP is involved in learning and epilepsy, it seems that copper effects on LTP could be associated with its effect...
متن کاملSeizures Induced by Pentylenetetrazole in the Adult Zebrafish: A Detailed Behavioral Characterization
Pentylenetetrazole (PTZ) is a common convulsant agent used in animal models to investigate the mechanisms of seizures. Although adult zebrafish have been recently used to study epileptic seizures, a thorough characterization of the PTZ-induced seizures in this animal model is missing. The goal of this study was to perform a detailed temporal behavior profile characterization of PTZ-induced seiz...
متن کاملClosed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish
Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex. Cortical norepinephrine then increases GABAergic transmission and increases seizure threshold. Another approach, responsive nervous stimulation...
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ژورنال
عنوان ژورنال: journal of applied pharmaceutical science
سال: 2023
ISSN: ['2231-3354']
DOI: https://doi.org/10.7324/japs.2023.133132